Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity

Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Accordingly, inhibition o...

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Publicado en:J Biol Chem
Autores principales: Nakano, Naoko, Sakata, Nobuo, Katsu, Yuki, Nochise, Daiki, Sato, Erika, Takahashi, Yuta, Yamaguchi, Saori, Haga, Yoko, Ikeno, Souichi, Motizuki, Mitsuyoshi, Sano, Keigo, Yamasaki, Kohei, Miyazawa, Keiji, Itoh, Susumu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335805/
https://ncbi.nlm.nih.gov/pubmed/32409577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013596
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