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The N-terminal domain of the non-receptor tyrosine kinase ABL confers protein instability and suppresses tumorigenesis

Chromosome translocation can lead to chimeric proteins that may become oncogenic drivers. A classic example is the fusion of the BCR activator of RhoGEF and GTPase and the ABL proto-oncogene nonreceptor tyrosine kinase, a result of a chromosome abnormality (Philadelphia chromosome) that causes leuke...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yan, Zhengwei, Shanmugasundaram, Karthigayan, Ma, Dongwen, Luo, Jiayu, Luo, Shiwen, Rao, Hai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335801/
https://ncbi.nlm.nih.gov/pubmed/32439806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012821
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