Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway

The Hippo pathway plays important roles in controlling organ size and in suppressing tumorigenesis through large tumor suppressor kinase 1/2 (LATS1/2)–mediated phosphorylation of YAP/TAZ transcription co-activators. The kinase activity of LATS1/2 is regulated by phosphorylation in response to extrac...

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Vydáno v:J Biol Chem
Hlavní autoři: Zhu, Chu, Ji, Xinyan, Zhang, Haitao, Zhou, Qi, Cao, Xiaolei, Tang, Mei, Si, Yuan, Yan, Huan, Li, Li, Liang, Tingbo, Feng, Xin-Hua, Zhao, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787797/
https://ncbi.nlm.nih.gov/pubmed/29183995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000392
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