Highly Efficient Gene Editing of Cystic Fibrosis Patient-Derived Airway Basal Cells Results in Functional CFTR Correction

There is a strong rationale to consider future cell therapeutic approaches for cystic fibrosis (CF) in which autologous proximal airway basal stem cells, corrected for CFTR mutations, are transplanted into the patient’s lungs. We assessed the possibility of editing the CFTR locus in these cells usin...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Suzuki, Shingo, Crane, Ana M., Anirudhan, Varada, Barillà, Cristina, Matthias, Nadine, Randell, Scott H., Rab, Andras, Sorscher, Eric J., Kerschner, Jenny L., Yin, Shiyi, Harris, Ann, Mendel, Matthew, Kim, Kenneth, Zhang, Lei, Conway, Anthony, Davis, Brian R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335734/
https://ncbi.nlm.nih.gov/pubmed/32402246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.04.021
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