Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor

HA plays a critical role in influenza infection and, thus HA is a potential target for antivirals. Recently, our laboratories have described a novel fusion inhibitor, termed CBS1117, with EC(50) ∼3 μM against group 1 HA. In this work, we characterize the binding properties of CBS1117 to avian H5 HA...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Antanasijevic, Aleksandar, Durst, Matthew A, Cheng, Han, Gaisina, Irina N, Perez, Jasmine T, Manicassamy, Balaji, Rong, Lijun, Lavie, Arnon, Caffrey, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335401/
https://ncbi.nlm.nih.gov/pubmed/32611549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000724
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