Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation

Autophagy is activated by prolonged fasting but cannot overcome the ensuing hepatic lipid overload, resulting in fatty liver. Here, we describe a peroxisome-lysosome metabolic link that restricts autophagic degradation of lipids. Acyl-CoA oxidase 1 (Acox1), the enzyme that catalyzes the first step i...

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Bibliographic Details
Published in:Mol Cell
Main Authors: He, Anyuan, Chen, Xiaowen, Tan, Min, Chen, Yali, Lu, Dongliang, Zhang, Xiangyu, Dean, John M., Razani, Babak, Lodhi, Irfan J.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335356/
https://ncbi.nlm.nih.gov/pubmed/32473093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.05.007
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