M(6)A demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia

N(6)-methyladenosine (m(6)A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m(6)A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia (AML), ALKBH5 was reported to be freque...

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Publicat a:Cell Stem Cell
Autors principals: Shen, Chao, Sheng, Yue, Zhu, Allen, Robinson, Sean, Jiang, Xi, Dong, Lei, Chen, Huiying, Su, Rui, Yin, Zhe, Li, Wei, Deng, Xiaolan, Chen, Yinhuai, Hu, Yueh-Chiang, Weng, Hengyou, Huang, Huilin, Prince, Emily, Cogle, Christopher R, Sun, Miao, Zhang, Bin, Chen, Chun-Wei, Marcucci, Guido, He, Chuan, Qian, Zhijian, Chen, Jianjun
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335338/
https://ncbi.nlm.nih.gov/pubmed/32402250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.04.009
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