M(6)A demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia

N(6)-methyladenosine (m(6)A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m(6)A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia (AML), ALKBH5 was reported to be freque...

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Publicado no:Cell Stem Cell
Main Authors: Shen, Chao, Sheng, Yue, Zhu, Allen, Robinson, Sean, Jiang, Xi, Dong, Lei, Chen, Huiying, Su, Rui, Yin, Zhe, Li, Wei, Deng, Xiaolan, Chen, Yinhuai, Hu, Yueh-Chiang, Weng, Hengyou, Huang, Huilin, Prince, Emily, Cogle, Christopher R, Sun, Miao, Zhang, Bin, Chen, Chun-Wei, Marcucci, Guido, He, Chuan, Qian, Zhijian, Chen, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335338/
https://ncbi.nlm.nih.gov/pubmed/32402250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.04.009
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