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Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

The amyloid conformation can be adopted by a variety of sequences, but the precise boundaries of amyloid sequence space are still unclear. The currently charted amyloid sequence space is strongly biased towards hydrophobic, beta-sheet prone sequences that form the core of globular proteins and by Q/...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Commun
मुख्य लेखकों: Louros, Nikolaos, Orlando, Gabriele, De Vleeschouwer, Matthias, Rousseau, Frederic, Schymkowitz, Joost
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2020
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335209/
https://ncbi.nlm.nih.gov/pubmed/32620861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17207-3
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