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Polyamine blockade and binding energetics in the MthK potassium channel

Polyamines such as spermidine and spermine are found in nearly all cells, at concentrations ranging up to 0.5 mM. These cations are endogenous regulators of cellular K(+) efflux, binding tightly in the pores of inwardly rectifying K(+) (K(ir)) channels in a voltage-dependent manner. Although the vol...

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Detalles Bibliográficos
Publicado en:J Gen Physiol
Autores principales: Suma, Antonio, Granata, Daniele, Thomson, Andrew S., Carnevale, Vincenzo, Rothberg, Brad S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335011/
https://ncbi.nlm.nih.gov/pubmed/32342093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201912527
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