NCLX prevents cell death during adrenergic activation of the brown adipose tissue

A sharp increase in mitochondrial Ca(2+) marks the activation of brown adipose tissue (BAT) thermogenesis, yet the mechanisms preventing Ca(2+) deleterious effects are poorly understood. Here, we show that adrenergic stimulation of BAT activates a PKA-dependent mitochondrial Ca(2+) extrusion via the...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Assali, Essam A., Jones, Anthony E., Veliova, Michaela, Acín-Pérez, Rebeca, Taha, Mahmoud, Miller, Nathanael, Shum, Michaël, Oliveira, Marcus F., Las, Guy, Liesa, Marc, Sekler, Israel, Shirihai, Orian S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334226/
https://ncbi.nlm.nih.gov/pubmed/32620768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16572-3
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