Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy

Autophagy is an essential cellular quality control process that has emerged as a critical one for vascular homeostasis. Here, we show that trichoplein (TCHP) links autophagy with endothelial cell (EC) function. TCHP localizes to centriolar satellites, where it binds and stabilizes PCM1. Loss of TCHP...

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Detalles Bibliográficos
Publicado en:EMBO Rep
Main Authors: Martello, Andrea, Lauriola, Angela, Mellis, David, Parish, Elisa, Dawson, John C, Imrie, Lisa, Vidmar, Martina, Gammoh, Noor, Mitić, Tijana, Brittan, Mairi, Mills, Nicholas L, Carragher, Neil O, D'Arca, Domenico, Caporali, Andrea
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
Assuntos:
Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7332983/
https://ncbi.nlm.nih.gov/pubmed/32337819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948192
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