Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)

We investigate mutations in trβ2, a splice variant of thrb, identifying changes in function, structure, and behavior in larval and adult zebrafish retinas. Two N-terminus CRISPR mutants were identified. The first is a 6BP+1 insertion deletion frameshift resulting in a truncated protein. The second i...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Deveau, Ciana, Jiao, Xiaodong, Suzuki, Sachihiro C., Krishnakumar, Asha, Yoshimatsu, Takeshi, Hejtmancik, J Fielding, Nelson, Ralph F.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7332105/
https://ncbi.nlm.nih.gov/pubmed/32569302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008869
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