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Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)
We investigate mutations in trβ2, a splice variant of thrb, identifying changes in function, structure, and behavior in larval and adult zebrafish retinas. Two N-terminus CRISPR mutants were identified. The first is a 6BP+1 insertion deletion frameshift resulting in a truncated protein. The second i...
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| Publicado no: | PLoS Genet |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7332105/ https://ncbi.nlm.nih.gov/pubmed/32569302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008869 |
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