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A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms

Motivated by growing evidence for pathway heterogeneity and alternative functions of molecular machines, we demonstrate a computational approach for investigating two questions: (1) Are there multiple mechanisms (state-space pathways) by which a machine can perform a given function, such as cotransp...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: George, August, Bisignano, Paola, Rosenberg, John M., Grabe, Michael, Zuckerman, Daniel M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331975/
https://ncbi.nlm.nih.gov/pubmed/32614821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007884
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