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ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins

Macroautophagy, the degradation of cytoplasmic content by lysosomal fusion, is an evolutionary conserved process promoting homeostasis and intracellular defence. Macroautophagy is initiated primarily by a complex containing ULK1 or ULK2 (two paralogs of the yeast Atg1 protein). To understand the dif...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Demeter, Amanda, Romero-Mulero, Mari Carmen, Csabai, Luca, Ölbei, Márton, Sudhakar, Padhmanand, Haerty, Wilfried, Korcsmáros, Tamás
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331686/
https://ncbi.nlm.nih.gov/pubmed/32616830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67780-2
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