Exploring the Post-Translational Enzymology of PaaA by mRNA Display

PaaA is a RiPP enzyme which catalyzes the transformation of two glutamic acid residues within a substrate peptide into the bicyclic core of Pantocin A. Here for the first time, we use mRNA display techniques to understand RiPP enzyme-substrate interactions to illuminate PaaA substrate recognition. A...

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Udgivet i:J Am Chem Soc
Main Authors: Fleming, Steven R., Himes, Paul M., Ghodge, Swapnil V., Goto, Yuki, Suga, Hiroaki, Bowers, Albert A.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330867/
https://ncbi.nlm.nih.gov/pubmed/32109054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c01576
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