EGFRvIII-specific CAR-T cells produced by piggyBac transposon exhibit efficient growth suppression against hepatocellular carcinoma

Adoptive cellular immunotherapy employing chimeric antigen receptors-modified T (CAR-T) cells has demonstrated promising antitumor effects in hematologic cancers. However, CAR-T therapy confront many challenges in solid tumors like immunosuppressive microenvironment, molecular heterogeneity, etc. Th...

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Detalhes bibliográficos
Publicado no:Int J Med Sci
Main Authors: Ma, Yuan, Chen, Yan, Yan, Lei, Cao, Hui-Xia, Han, Shuang-Yin, Cui, Jun-Jun, Wen, Jian Guo, Zheng, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330669/
https://ncbi.nlm.nih.gov/pubmed/32624697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.45603
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