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RIF1 controls replication initiation and homologous recombination repair in a radiation dose-dependent manner

RIF1 controls both DNA replication timing and the DNA double-strand break (DSB) repair pathway to maintain genome integrity. However, it remains unclear how RIF1 links these two processes following exposure to ionizing radiation (IR). Here, we show that inhibition of homologous recombination repair...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Saito, Yuichiro, Kobayashi, Junya, Kanemaki, Masato T., Komatsu, Kenshi
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328141/
https://ncbi.nlm.nih.gov/pubmed/32434870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.240036
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