Liver-specific ceramide reduction alleviates steatosis and insulin resistance in alcohol-fed mice

Alcohol’s impairment of both hepatic lipid metabolism and insulin resistance (IR) are key drivers of alcoholic steatosis, the initial stage of alcoholic liver disease (ALD). Pharmacologic reduction of lipotoxic ceramide prevents alcoholic steatosis and glucose intolerance in mice, but potential off-...

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Détails bibliographiques
Publié dans:J Lipid Res
Auteurs principaux: Correnti, Jason, Lin, Chelsea, Brettschneider, Jascha, Kuriakose, Amy, Jeon, Sookyoung, Scorletti, Eleonora, Oranu, Amanke, McIver-Jenkins, Dru, Kaneza, Isabelle, Buyco, Delfin, Saiman, Yedidya, Furth, Emma E., Argemi, Josepmaria, Bataller, Ramon, Holland, William L., Carr, Rotonya M.
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2020
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328039/
https://ncbi.nlm.nih.gov/pubmed/32398264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000446
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