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Liver-specific ceramide reduction alleviates steatosis and insulin resistance in alcohol-fed mice
Alcohol’s impairment of both hepatic lipid metabolism and insulin resistance (IR) are key drivers of alcoholic steatosis, the initial stage of alcoholic liver disease (ALD). Pharmacologic reduction of lipotoxic ceramide prevents alcoholic steatosis and glucose intolerance in mice, but potential off-...
Enregistré dans:
| Publié dans: | J Lipid Res |
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| Auteurs principaux: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Biochemistry and Molecular Biology
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7328039/ https://ncbi.nlm.nih.gov/pubmed/32398264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000446 |
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