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Liver-specific ceramide reduction alleviates steatosis and insulin resistance in alcohol-fed mice
Alcohol’s impairment of both hepatic lipid metabolism and insulin resistance (IR) are key drivers of alcoholic steatosis, the initial stage of alcoholic liver disease (ALD). Pharmacologic reduction of lipotoxic ceramide prevents alcoholic steatosis and glucose intolerance in mice, but potential off-...
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| 出版年: | J Lipid Res |
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| 主要な著者: | , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Biochemistry and Molecular Biology
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7328039/ https://ncbi.nlm.nih.gov/pubmed/32398264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000446 |
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