Liver-specific ceramide reduction alleviates steatosis and insulin resistance in alcohol-fed mice

Alcohol’s impairment of both hepatic lipid metabolism and insulin resistance (IR) are key drivers of alcoholic steatosis, the initial stage of alcoholic liver disease (ALD). Pharmacologic reduction of lipotoxic ceramide prevents alcoholic steatosis and glucose intolerance in mice, but potential off-...

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Библиографические подробности
Опубликовано в: :J Lipid Res
Главные авторы: Correnti, Jason, Lin, Chelsea, Brettschneider, Jascha, Kuriakose, Amy, Jeon, Sookyoung, Scorletti, Eleonora, Oranu, Amanke, McIver-Jenkins, Dru, Kaneza, Isabelle, Buyco, Delfin, Saiman, Yedidya, Furth, Emma E., Argemi, Josepmaria, Bataller, Ramon, Holland, William L., Carr, Rotonya M.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Biochemistry and Molecular Biology 2020
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328039/
https://ncbi.nlm.nih.gov/pubmed/32398264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000446
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