Liver-specific ceramide reduction alleviates steatosis and insulin resistance in alcohol-fed mice

Alcohol’s impairment of both hepatic lipid metabolism and insulin resistance (IR) are key drivers of alcoholic steatosis, the initial stage of alcoholic liver disease (ALD). Pharmacologic reduction of lipotoxic ceramide prevents alcoholic steatosis and glucose intolerance in mice, but potential off-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Lipid Res
Prif Awduron: Correnti, Jason, Lin, Chelsea, Brettschneider, Jascha, Kuriakose, Amy, Jeon, Sookyoung, Scorletti, Eleonora, Oranu, Amanke, McIver-Jenkins, Dru, Kaneza, Isabelle, Buyco, Delfin, Saiman, Yedidya, Furth, Emma E., Argemi, Josepmaria, Bataller, Ramon, Holland, William L., Carr, Rotonya M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328039/
https://ncbi.nlm.nih.gov/pubmed/32398264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000446
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