The impact of pre-existing HLA and red blood cell antibodies on transfusion support and engraftment in sickle cell disease after nonmyeloablative hematopoietic stem cell transplantation from HLA-matched sibling donors: A prospective, single-center, observational study

BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is curative for patients with sickle cell disease (SCD). Prior to HSCT, patients with SCD commonly receive RBC transfusions with some becoming RBC or HLA alloimmunized. This alloimmunization may impact post-HSCT transfusion requirements and...

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Detalhes bibliográficos
Publicado no:EClinicalMedicine
Main Authors: Nickel, Robert Sheppard, Flegel, Willy A., Adams, Sharon D., Hendrickson, Jeanne E., Liang, Hua, Tisdale, John F., Hsieh, Matthew M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327930/
https://ncbi.nlm.nih.gov/pubmed/32637902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eclinm.2020.100432
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