Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics

Ancestral sequence reconstruction is a powerful method for inferring ancestors of modern enzymes and for studying structure–function relationships of enzymes. We have previously applied this approach to haloalkane dehalogenases (HLDs) from the subfamily HLD-II and obtained thermodynamically highly s...

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Pubblicato in:Comput Struct Biotechnol J
Autori principali: Babkova, Petra, Dunajova, Zuzana, Chaloupkova, Radka, Damborsky, Jiri, Bednar, David, Marek, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Research Network of Computational and Structural Biotechnology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327271/
https://ncbi.nlm.nih.gov/pubmed/32637047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.06.021
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