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Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics
Ancestral sequence reconstruction is a powerful method for inferring ancestors of modern enzymes and for studying structure–function relationships of enzymes. We have previously applied this approach to haloalkane dehalogenases (HLDs) from the subfamily HLD-II and obtained thermodynamically highly s...
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| Publié dans: | Comput Struct Biotechnol J |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Research Network of Computational and Structural Biotechnology
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7327271/ https://ncbi.nlm.nih.gov/pubmed/32637047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.06.021 |
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