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Conformational changes allow processing of bulky substrates by a haloalkane dehalogenase with a small and buried active site

Haloalkane dehalogenases catalyze the hydrolysis of halogen–carbon bonds in organic halogenated compounds and as such are of great utility as biocatalysts. The crystal structures of the haloalkane dehalogenase DhlA from the bacterium from Xanthobacter autotrophicus GJ10, specifically adapted for the...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Kokkonen, Piia, Bednar, David, Dockalova, Veronika, Prokop, Zbynek, Damborsky, Jiri
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065182/
https://ncbi.nlm.nih.gov/pubmed/29858243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000328
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