Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP

Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates. Importantly, although ADEP-activated ClpP is assumed to target multi...

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Publicat a:mBio
Autors principals: Silber, Nadine, Pan, Stefan, Schäkermann, Sina, Mayer, Christian, Brötz-Oesterhelt, Heike, Sass, Peter
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327170/
https://ncbi.nlm.nih.gov/pubmed/32605984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01006-20
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