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Poncirin Inhibits Osteoclast Differentiation and Bone Loss through Down-Regulation of NFATc1 In Vitro and In Vivo

Activation of osteoclast and inactivation of osteoblast result in loss of bone mass with bone resorption, leading to the pathological progression of osteoporosis. The receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily, and is a key mediator of osteoclast differentiation. A...

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Publicat a:Biomol Ther (Seoul)
Autors principals: Chun, Kwang-Hoon, Jin, Hyun Chul, Kang, Ki Sung, Chang, Tong-Shin, Hwang, Gwi Seo
Format: Artigo
Idioma:Inglês
Publicat: The Korean Society of Applied Pharmacology 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327144/
https://ncbi.nlm.nih.gov/pubmed/31500404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2018.216
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