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Negative Feedback Control of Osteoclast Formation through Ubiquitin-mediated Down-regulation of NFATc1
The regulation of NFATc1 expression is important for osteoclast differentiation and function. Herein, we demonstrate that macrophage-colony-stimulating factor induces NFATc1 degradation via Cbl proteins in a Src kinase-dependent manner. NFATc1 proteins are ubiquitinated and rapidly degraded during l...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820750/ https://ncbi.nlm.nih.gov/pubmed/20037154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042812 |
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