Negative Feedback Control of Osteoclast Formation through Ubiquitin-mediated Down-regulation of NFATc1

The regulation of NFATc1 expression is important for osteoclast differentiation and function. Herein, we demonstrate that macrophage-colony-stimulating factor induces NFATc1 degradation via Cbl proteins in a Src kinase-dependent manner. NFATc1 proteins are ubiquitinated and rapidly degraded during l...

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Detaylı Bibliyografya
Asıl Yazarlar: Kim, Jung Ha, Kim, Kabsun, Jin, Hye Mi, Song, Insun, Youn, Bang Ung, Lee, Seoung-Hoon, Choi, Yongwon, Kim, Nacksung
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Gene Regulation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820750/
https://ncbi.nlm.nih.gov/pubmed/20037154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042812
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