Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells

Cholesterol accumulation in late endosomes is a prevailing phenotype of Niemann-Pick type C1 (NPC1) mutant cells. Likewise, annexin A6 (AnxA6) overexpression induces a phenotype reminiscent of NPC1 mutant cells. Here, we demonstrate that this cellular cholesterol imbalance is due to AnxA6 promoting...

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Udgivet i:Cell Mol Life Sci
Main Authors: Meneses-Salas, Elsa, García-Melero, Ana, Kanerva, Kristiina, Blanco-Muñoz, Patricia, Morales-Paytuvi, Frederic, Bonjoch, Júlia, Casas, Josefina, Egert, Antonia, Beevi, Syed S., Jose, Jaimy, Llorente-Cortés, Vicenta, Rye, Kerry-Anne, Heeren, Joerg, Lu, Albert, Pol, Albert, Tebar, Francesc, Ikonen, Elina, Grewal, Thomas, Enrich, Carlos, Rentero, Carles
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2019
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326902/
https://ncbi.nlm.nih.gov/pubmed/31664461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03330-y
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