Selective Degradation Permits a Feedback Loop Controlling Annexin A6 and Cholesterol Levels in Endolysosomes of NPC1 Mutant Cells

We recently identified elevated annexin A6 (AnxA6) protein levels in Niemann–Pick-type C1 (NPC1) mutant cells. In these cells, AnxA6 depletion rescued the cholesterol accumulation associated with NPC1 deficiency. Here, we demonstrate that elevated AnxA6 protein levels in NPC1 mutants or upon pharmac...

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Publicado en:Cells
Main Authors: Meneses-Salas, Elsa, García-Melero, Ana, Blanco-Muñoz, Patricia, Jose, Jaimy, Brenner, Marie-Sophie, Lu, Albert, Tebar, Francesc, Grewal, Thomas, Rentero, Carles, Enrich, Carlos
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7291204/
https://ncbi.nlm.nih.gov/pubmed/32392809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051152
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