Human Single-chain Variable Fragments Neutralize Pseudomonas aeruginosa Quorum Sensing Molecule, 3O-C12-HSL, and Prevent Cells From the HSL-mediated Apoptosis

The quorum sensing (QS) signaling molecule, N-(3-oxododecanoyl)-L-homoserine lactone (3O-C12-HSL), contributes to the pathogenesis of Pseudomonas aeruginosa by regulating expression of the bacterial virulence factors that cause intense inflammation and toxicity in the infected host. As such, the QS...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Santajit, Sirijan, Seesuay, Watee, Mahasongkram, Kodchakorn, Sookrung, Nitat, Pumirat, Pornpan, Ampawong, Sumate, Reamtong, Onrapak, Chongsa-Nguan, Manas, Chaicumpa, Wanpen, Indrawattana, Nitaya
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326786/
https://ncbi.nlm.nih.gov/pubmed/32670218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.01172
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