Systematic engineering of branch chain amino acid supply modules for the enhanced production of bacitracin from Bacillus licheniformis

Bacitracin is a broad-spectrum cyclic peptide antibiotic mainly produced by Bacillus, precursor amino acid supply served as the critical role during its synthesis. In this study, we systematically engineered branch-chain amino acid (BCAA) supply modules for bacitracin production. Firstly, we demonst...

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Publicado en:Metab Eng Commun
Autores principales: Cai, Dongbo, Zhu, Jiang, Li, Yang, Li, Lingfeng, Zhang, Meng, Wang, Zhi, Yang, Hanbo, Li, Junhui, Yang, Zhifan, Chen, Shouwen
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326738/
https://ncbi.nlm.nih.gov/pubmed/32637317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mec.2020.e00136
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