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N-acetylcysteine mitigates acute opioid withdrawal behaviors and CNS oxidative stress in neonatal rats
BACKGROUND: Neonatal abstinence syndrome (NAS) is a significant problem. Opioid withdrawal induces oxidative stress and disrupts glutamate and glutathione homeostasis. We hypothesized that N-acetylcysteine (NAC) administered during acute opioid withdrawal in neonatal rats would decrease withdrawal b...
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| Vydáno v: | Pediatr Res |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group US
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7326708/ https://ncbi.nlm.nih.gov/pubmed/31935745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41390-019-0728-6 |
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