N-acetylcysteine mitigates acute opioid withdrawal behaviors and CNS oxidative stress in neonatal rats

BACKGROUND: Neonatal abstinence syndrome (NAS) is a significant problem. Opioid withdrawal induces oxidative stress and disrupts glutamate and glutathione homeostasis. We hypothesized that N-acetylcysteine (NAC) administered during acute opioid withdrawal in neonatal rats would decrease withdrawal b...

Full description

Saved in:
Bibliographic Details
Published in:Pediatr Res
Main Authors: Ward, Price, Moss, Hunter G., Brown, Truman R., Kalivas, Peter, Jenkins, Dorothea D.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group US 2020
Subjects:
Basic Science Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326708/
https://ncbi.nlm.nih.gov/pubmed/31935745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41390-019-0728-6
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items