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N-Acetylcysteine rapidly replenishes central nervous system glutathione measured via magnetic resonance spectroscopy in human neonates with hypoxic-ischemic encephalopathy

Persistent oxidative stress depletes reduced glutathione (GSH), an intracellular antioxidant and an important determinant of CNS injury after hypoxia ischemia. We used standard, short echo time Stimulated Echo Acquisition Mode (STEAM) to detect GSH by magnetic resonance spectroscopy (MRS) in 24 term...

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Pubblicato in:J Cereb Blood Flow Metab
Autori principali: Moss, Hunter G, Brown, Truman R, Wiest, Donald B, Jenkins, Dorothea D
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999009/
https://ncbi.nlm.nih.gov/pubmed/29561203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X18765828
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