N-Acetylcysteine rapidly replenishes central nervous system glutathione measured via magnetic resonance spectroscopy in human neonates with hypoxic-ischemic encephalopathy

Persistent oxidative stress depletes reduced glutathione (GSH), an intracellular antioxidant and an important determinant of CNS injury after hypoxia ischemia. We used standard, short echo time Stimulated Echo Acquisition Mode (STEAM) to detect GSH by magnetic resonance spectroscopy (MRS) in 24 term...

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Publicat a:J Cereb Blood Flow Metab
Autors principals: Moss, Hunter G, Brown, Truman R, Wiest, Donald B, Jenkins, Dorothea D
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2018
Matèries:
Rapid Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999009/
https://ncbi.nlm.nih.gov/pubmed/29561203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X18765828
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