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N-Acetylcysteine rapidly replenishes central nervous system glutathione measured via magnetic resonance spectroscopy in human neonates with hypoxic-ischemic encephalopathy

Persistent oxidative stress depletes reduced glutathione (GSH), an intracellular antioxidant and an important determinant of CNS injury after hypoxia ischemia. We used standard, short echo time Stimulated Echo Acquisition Mode (STEAM) to detect GSH by magnetic resonance spectroscopy (MRS) in 24 term...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Moss, Hunter G, Brown, Truman R, Wiest, Donald B, Jenkins, Dorothea D
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999009/
https://ncbi.nlm.nih.gov/pubmed/29561203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X18765828
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