Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E

Newcastle disease virus (NDV), a member of the Paramyxoviridae family, can activate PKR/eIF2α signaling cascade to shutoff host and facilitate viral mRNA translation during infection, however, the mechanism remains unclear. In this study, we revealed that NDV infection up-regulated host cap-dependen...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Zhan, Yuan, Yu, Shengqing, Yang, Shen, Qiu, Xusheng, Meng, Chunchun, Tan, Lei, Song, Cuiping, Liao, Ying, Liu, Weiwei, Sun, Yingjie, Ding, Chan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326156/
https://ncbi.nlm.nih.gov/pubmed/32603377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008610
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