Gene Expression Profiling of PDGFRA Mutant GIST Reveals Immune Signatures as a Specific Fingerprint of D842V Exon 18 Mutation

Platelet Derived Growth Factor Receptor Alpha (PDGFRA) mutations occur in only about 5–7% of gastrointestinal stromal tumors (GIST), notably with alterations on exons 12/14/18. The most frequent PDGFRA mutation is the exon 18 D842V, which is correlated to specific clinico-pathological features, such...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Indio, Valentina, Ravegnini, Gloria, Astolfi, Annalisa, Urbini, Milena, Saponara, Maristella, De Leo, Antonio, Gruppioni, Elisa, Tarantino, Giuseppe, Angelini, Sabrina, Pession, Andrea, Pantaleo, Maria Abbondanza, Nannini, Margherita
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326057/
https://ncbi.nlm.nih.gov/pubmed/32670260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00851
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