Discovery of IAP-Recruiting BCL-X(L) PROTACs as Potent Degraders across Multiple Cancer Cell Lines

Targeting BCL-X(L) via PROTACs is a promising strategy in reducing BCL-X(L) inhibition associated platelet toxicity. Recently, we reported potent BCL-X(L) PROTAC degraders that recruit VHL or CRBN E3 ligase. However, low protein expression or mutation of the responsible E3 ligase has been known to r...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Zhang, Xuan, He, Yonghan, Zhang, Peiyi, Budamagunta, Vivekananda, Lv, Dongwen, Thummuri, Dinesh, Yang, Yang, Pei, Jing, Yuan, Yaxia, Zhou, Daohong, Zheng, Guangrong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325632/
https://ncbi.nlm.nih.gov/pubmed/32388279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112397
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