Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking

BACKGROUND: Lymphocytes circulate between peripheral lymphoid tissues via blood and lymphatic systems, and chemokine-induced migration is important in trafficking lymphocytes to distant sites. The small GTPase Rap1 is important in mediating lymphocyte motility, and Rap1-GEFs are involved in chemokin...

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Veröffentlicht in:BMC Biol
Hauptverfasser: Ishihara, Sayaka, Sato, Tsuyoshi, Du, Guangwei, Guardavaccaro, Daniele, Nakajima, Akihiko, Sawai, Satoshi, Kataoka, Tohru, Katagiri, Koko
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325102/
https://ncbi.nlm.nih.gov/pubmed/32600317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00809-0
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