Differential Activation of P-TEFb Complexes in the Development of Cardiomyocyte Hypertrophy following Activation of Distinct G Protein-Coupled Receptors

Pathological cardiac hypertrophy is driven by neurohormonal activation of specific G protein-coupled receptors (GPCRs) in cardiomyocytes and is accompanied by large-scale changes in cardiomyocyte gene expression. These transcriptional changes require activity of positive transcription elongation fac...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Martin, Ryan D., Sun, Yalin, MacKinnon, Sarah, Cuccia, Luca, Pagé, Viviane, Hébert, Terence E., Tanny, Jason C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324848/
https://ncbi.nlm.nih.gov/pubmed/32341082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00048-20
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