A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding

Helicobacter pylori (H. pylori) secretes the chaperone and serine protease high temperature requirement A (HtrA) that cleaves gastric epithelial cell surface proteins to disrupt the epithelial integrity and barrier function. First inhibitory lead structures have demonstrated the essential role of Ht...

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Publicado no:Sci Rep
Main Authors: Bernegger, Sabine, Brunner, Cyrill, Vizovišek, Matej, Fonovic, Marko, Cuciniello, Gaetano, Giordano, Flavia, Stanojlovic, Vesna, Jarzab, Miroslaw, Simister, Philip, Feller, Stephan M., Obermeyer, Gerhard, Posselt, Gernot, Turk, Boris, Cabrele, Chiara, Schneider, Gisbert, Wessler, Silja
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324608/
https://ncbi.nlm.nih.gov/pubmed/32601479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67578-2
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