Mechanistic insights on the mode of action of an antiproliferative thiosemicarbazone-nickel complex revealed by an integrated chemogenomic profiling study

Thiosemicarbazones (TSC) and their metal complexes display diverse biological activities and are active against multiple pathological conditions ranging from microbial infections to abnormal cell proliferation. Ribonucleotide reductase (RNR) is considered one of the main targets of TSCs, yet, the ex...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Baruffini, Enrico, Ruotolo, Roberta, Bisceglie, Franco, Montalbano, Serena, Ottonello, Simone, Pelosi, Giorgio, Buschini, Annamaria, Lodi, Tiziana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324377/
https://ncbi.nlm.nih.gov/pubmed/32601343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67439-y
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