Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL

Children and adults with Philadelphia chromosome–like B cell acute lymphoblastic leukemia (Ph-like B-ALL) experience high relapse rates despite best-available conventional chemotherapy. Ph-like ALL is driven by genetic alterations that activate constitutive cytokine receptor and kinase signaling, an...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Hurtz, Christian, Wertheim, Gerald B., Loftus, Joseph P., Blumenthal, Daniel, Lehman, Anne, Li, Yong, Bagashev, Asen, Manning, Bryan, Cummins, Katherine D., Burkhardt, Janis K., Perl, Alexander E., Carroll, Martin, Tasian, Sarah K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324172/
https://ncbi.nlm.nih.gov/pubmed/32191635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134424
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