Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL

Children and adults with Philadelphia chromosome–like B cell acute lymphoblastic leukemia (Ph-like B-ALL) experience high relapse rates despite best-available conventional chemotherapy. Ph-like ALL is driven by genetic alterations that activate constitutive cytokine receptor and kinase signaling, an...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Hurtz, Christian, Wertheim, Gerald B., Loftus, Joseph P., Blumenthal, Daniel, Lehman, Anne, Li, Yong, Bagashev, Asen, Manning, Bryan, Cummins, Katherine D., Burkhardt, Janis K., Perl, Alexander E., Carroll, Martin, Tasian, Sarah K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324172/
https://ncbi.nlm.nih.gov/pubmed/32191635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134424
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