Variants in ADRB1 and CYP2C9: Association with Response to Atenolol and Losartan in Marfan Syndrome

OBJECTIVE: To test whether variants in ADRB1 and CYP2C9 genes identify subgroups of individuals with differential response to treatment for Marfan syndrome through analysis of data from a large randomized trial. STUDY DESIGN: In a subset of 250 white, non-Hispanic participants with Marfan syndrome i...

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Publicado no:J Pediatr
Main Authors: Van Driest, Sara L., Sleeper, Lynn A., Gelb, Bruce D., Morris, Shaine A., Dietz, Harry C., Forbus, Geoffrey A., Goldmuntz, Elizabeth, Hoskoppal, Arvind, James, Jeanne, Lee, Teresa M., Levine, Jami C., Li, Jennifer S., Loeys, Bart L., Markham, Larry W., Meester, Josephina A. N., Mital, Seema, Mosley, Jonathan D., Olson, Aaron K., Renard, Marjolijn, Shaffer, Christian M., Sharkey, Angela, Young, Luciana, Lacro, Ronald V., Roden, Dan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7323908/
https://ncbi.nlm.nih.gov/pubmed/32586526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2020.03.064
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