A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors

OBJECTIVES: SLC-0111 is an ureido-substituted benzenesulfonamide small molecule inhibitor of carbonic anhydrase IX. The objectives of this first-in-human Phase 1 study were to determine the safety and tolerability of SLC-0111 in patients with advanced solid tumors and to establish the recommended Ph...

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Pubblicato in:Am J Clin Oncol
Autori principali: McDonald, Paul C., Chia, Stephen, Bedard, Philippe L., Chu, Quincy, Lyle, Michael, Tang, Liren, Singh, Madhu, Zhang, Zaihui, Supuran, Claudiu T., Renouf, Daniel J., Dedhar, Shoukat
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2020
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Original Articles: Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7323835/
https://ncbi.nlm.nih.gov/pubmed/32251122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COC.0000000000000691
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