RIG-I and TLR4 Responses and Adverse Outcomes in Pediatric Influenza-Related Critical Illness

BACKGROUND: Decreased tumor necrosis factor (TNF)-α production in whole blood following ex vivo lipopolysaccharide (LPS) stimulation indicates suppression of the toll-like receptor (TLR)4 pathway. This is associated with increased mortality in pediatric influenza critical illness. Whether anti-viral...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Novak, Tanya, Hall, Mark W., McDonald, Douglas R., Newhams, Margaret M., Mistry, Anushay J., Panoskaltsis-Mortari, Angela, Mourani, Peter M., Loftis, Laura L., Weiss, Scott L., Tarquinio, Keiko M., Markovitz, Barry, Hartman, Mary E., Schwarz, Adam, Junger, Wolfgang G., Randolph, Adrienne G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7323584/
https://ncbi.nlm.nih.gov/pubmed/32035159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.01.040
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