Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analyses at effective plasma concentrations utilizing UPLC-MS/MS

Exenatide is the first approved glucagon-like peptide 1 receptor agonist subcutaneously or intramuscularly injected for the treatment of type 2 diabetes mellitus. Typical therapeutic plasma concentrations are in the low pg/mL range, therefore requiring ultra-sensitive quantification. To enable the a...

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Detaylı Bibliyografya
Yayımlandı:J Pharm Anal
Asıl Yazarlar: Sauter, Max, Uhl, Philipp, Burhenne, Jürgen, Haefeli, Walter E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Xi'an Jiaotong University 2020
Konular:
Original article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322758/
https://ncbi.nlm.nih.gov/pubmed/32612869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2020.02.008
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