An Accurate and Effective Method for Measuring Osimertinib by UPLC-TOF-MS and Its Pharmacokinetic Study in Rats

Osimertinib, a new-generation inhibitor of the epidermal growth factor, has been used for the clinical treatment of advanced T790M mutation-positive tumors. In this research, an original analysis method was established for the quantification of osimertinib by ultra-performance liquid chromatography...

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Udgivet i:Molecules
Main Authors: Dong, Song-Tao, Li, Ying, Yang, Hao-Tian, Wu, Yin, Li, Ya-Jing, Ding, Cong-Yang, Meng, Lu, Dong, Zhan-Jun, Zhang, Yuan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278556/
https://ncbi.nlm.nih.gov/pubmed/30404182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23112894
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