Twist1 induces chromosomal instability (CIN) in colorectal cancer cells

Twist1 is a basic helix-loop-helix transcription factor, essential during early development in mammals. While Twist1 induces epithelial-to-mesenchymal transition (EMT), here we show that Twist1 overexpression enhances nuclear and mitotic aberrations. This is accompanied by an increase in whole chrom...

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Publicado en:Hum Mol Genet
Autores principales: Khot, Maithilee, Sreekumar, Dyuthi, Jahagirdar, Sanika, Kulkarni, Apoorva, Hari, Kishore, Faseela, Elangoli Ebrahimkutty, Sabarinathan, Radhakrishnan, Jolly, Mohit Kumar, Sengupta, Kundan
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322571/
https://ncbi.nlm.nih.gov/pubmed/32337580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa076
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