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A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer

The Tn antigen is a well-known tumor-associated carbohydrate determinant, often incorporated in glycopeptides to develop cancer vaccines. Herein, four copies of a conformationally constrained mimetic of the antigen TnThr (GalNAc-Thr) were conjugated to the adjuvant CRM197, a protein licensed for hum...

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Publicado en:iScience
Autores principales: Amedei, Amedeo, Asadzadeh, Fatemeh, Papi, Francesco, Vannucchi, Maria Giuliana, Ferrucci, Veronica, Bermejo, Iris A., Fragai, Marco, De Almeida, Carolina Vieira, Cerofolini, Linda, Giuntini, Stefano, Bombaci, Mauro, Pesce, Elisa, Niccolai, Elena, Natali, Francesca, Guarini, Eleonora, Gabel, Frank, Traini, Chiara, Catarinicchia, Stefano, Ricci, Federica, Orzalesi, Lorenzo, Berti, Francesco, Corzana, Francisco, Zollo, Massimo, Grifantini, Renata, Nativi, Cristina
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322362/
https://ncbi.nlm.nih.gov/pubmed/32629615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101250
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